Research Research Highlights
Research Highlights
Research Highlights
Research Highlights
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![The Secret to Satiety Unveiled by Seoul National University Researchers!](/webdata/boardimages/enhighlight/d97z1cfz1a9za1bz93dz8a1z817ze02z714z9c6z75.png)
The Secret to Satiety Unveiled by Seoul National University Researchers!
Prof. Hyung Jin Choi
Professor Hyung Jin Choi's research team from the Department of Brain and Cognitive Sciences at Seoul National University has announced that they have identified the mechanism by which 'glucagon-like peptide-1 (GLP-1)' based obesity treatments reduce body weight for the first time in the world.
Research Highlights Board
![3D Printing with a 3D Printed Digital Material Filament for Programming Functional Gradients](/webdata/boardimages/enhighlight/1b4z749z0d1za85zf91zd65zef9zc1bz875z9d0zba.png)
3D Printing with a 3D Printed Digital Material Filament for Programming Functional Gradients
Prof. Howon Lee and Kyu-Jin Cho
Additive manufacturing, or 3D printing attracts growing attention as a promising method for creating functionally graded materials.
![Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA](/webdata/boardimages/enhighlight/170zccezf57z0cazb7dzf1ez434za66z8a0z3f9zff.png)
Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA
Prof. Martin Steinegger
Metagenomic taxonomic classifiers analyze either DNA or amino acid (AA) sequences. Metabuli (https://metabuli.steineggerlab.com), however, jointly analyzes both DNA and AA to leverage AA conservation for sensitive homology detection and DNA mutations for specific differentiation of closely related taxa. In the Critical...
![Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways](/webdata/boardimages/enhighlight/5f4z5d2zc0bz73bzdaczde1z9f9z4a3zc3eza09z7d.png)
Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways
Prof. Hyuk-Jin Cha
Precise genome editing is crucial for establishing isogenic human disease models and ex vivo stem cell therapy from the patient-derived hPSCs.
![Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior](/webdata/boardimages/enhighlight/50cz3e7z6bbzc6fz5c0z00fzc0ez5d2z3caz249zda.png)
Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior
Prof. Hyung Jin Choi
Professor choi’s research team from the SNU demonstrated that activation of LHAGABA neurons in non-human primate drives naturalistic goal-directed eating behavior and motivation, predominantly for palatable food.
![Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions](/webdata/boardimages/enhighlight/d8ez48fz037z8daz2fbza15zfe6z690zee4z06fz94.png)
Optogenetic control of mRNA condensation reveals an intimate link between condensate material properties and functions
Prof. Yongdae Shin
Biomolecular condensates, often assembled through phase transition mechanisms, play key roles in organizing diverse cellular activities. The material properties of condensates, ranging from liquid droplets to solid-like glasses or gels, are key features impacting the way resident components associate with one another.
![Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition](/webdata/boardimages/enhighlight/f55z81ezc51zbe3zf9az3e5z23ez391z6afz5dfz3d.png)
Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition
Prof. Jung Pyo Lee, Seung Hee Yang
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of antibiotic-induced microbiota depletion (AIMD) on this transition.
![Strain-Insensitive Outdoor Wearable Electronics by Thermally Robust Nanofibrous Radiative Cooler](/webdata/boardimages/enhighlight/10fzf43zdcez031ze09zd3czb8fz8fbzd57z80dz91.png)
Strain-Insensitive Outdoor Wearable Electronics by Thermally Robust Nanofibrous Radiative Cooler
Prof. Seung Hwan Ko
Stable outdoor wearable electronics are gaining attention due to challenges in sustaining consistent device performance outdoors, where sunlight exposure and user movement can disrupt operations.
![Discovery of Terminal Oxazole-Bearing Natural Products by a Targeted Metabologenomic Approach](/webdata/boardimages/enhighlight/888z67fzb23z145z674z109z43dz8c8zce6z290z06.png)
Discovery of Terminal Oxazole-Bearing Natural Products by a Targeted Metabologenomic Approach
Prof. Dong-Chan Oh
A targeted metabologenomic method was developed to selectively discover terminal oxazole-bearing natural products from bacteria. For this, genes encoding oxazole cyclase, a key enzyme in terminal oxazole biosynthesis, were chosen as the genomic signature to screen bacterial strains that may produce oxazole-bearing compounds.
![Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres](/webdata/boardimages/enhighlight/412z128zfdez286z3c1z3eaz079z368z7a9zebdz23.png)
Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres
Prof. Hyunsook Lee
Dynamic interaction between BRCA2 and telomeric G-quadruplexes (G4) is crucial for maintaining telomere replication homeostasis. Cells lacking BRCA2 display telomeric damage with a subset of these cells bypassing senescence to initiate break-induced replication (BIR) for telomere synthesis.
![Phytohormonal regulation determines the organization pattern of shoot aerenchyma in greater duckweed (<i>Spirodela polyrhiza</i>)](/webdata/boardimages/enhighlight/087z4e4zbb1zb8eza33z6f6z4c1zea6z7dbzfe0z3c.png)
Phytohormonal regulation determines the organization pattern of shoot aerenchyma in greater duckweed (Spirodela polyrhiza)
Prof. Daehee Hwang and Yuree Lee
Airspace or aerenchyma is crucial for plant development and acclimation to stresses such as hypoxia, drought, and nutritional deficiency. Although ethylene-mediated signaling cascades are known to regulate aerenchyma formation in stems and roots under hypoxic conditions, the precise mechanisms remain unclear.
![Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex](/webdata/boardimages/enhighlight/a1cz898z35dz32az69fz7dez5d3ze4az8c5zbd7za0.png)
Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex
Prof. Ho Jae Han
Damaged mitochondria accumulation in diabetes is one of the main features that contribute to increased incidence of cognitive impairment by inducing apoptosis. Butyrate is a major metabolite produced by microbiota that has neuroprotective effects by regulating mitochondrial function.