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A sustained high-temperature fusion plasma regime facilitated by fast ions
Prof. Yong-Su Na
Nuclear fusion is one of the most attractive alternatives to carbon-dependent energy sources1. Harnessing energy from nuclear fusion in a large reactor scale, however, still presents many scientific challenges despite the many years of research and steady advances in magnetic confinement approaches.
Research Highlights Board
Targeted erasing of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
Prof. Jae Bum Kim
DNA methylation is a crucial epigenetic modification in the establishment of cell-type-specific characteristics. However, how DNA methylation is selectively reprogrammed at adipocyte-specific loci during adipogenesis remains unclear.
Essential cues of engineered polymeric materials regulating gene transfer pathways
Prof. Cheol-Heui Yun & Prof. Chong-Su Cho
Regulating cellular uptake pathways using engineered materials is becoming a vital strategy for efficient gene transfer because the success of gene delivery most often relies on the uptake mechanism and the intracellular fate of the delivery vectors.
MSD2-mediated ROS metabolism fine-tunes the timing of floral organ abscission in Arabidopsis
Prof. Yuree Lee
The timely removal of end-of-purpose flowering organs is as essential for reproduction and plant survival as timely flowering. Despite much progress in understanding the molecular mechanisms of floral organ abscission, little is known about how various environmental factors are integrated into developmental programmes that determine the timing of abscission.
Admixture of divergent genomes facilitates hybridization across species in the family Brassicaceae
Prof. Jin Hoe Huh
Hybridization and polyploidization are pivotal to plant evolution. Genetic crosses between distantly related species are rare in nature due to reproductive barriers but how such hurdles can be overcome is largely unknown.
Complex regulatory networks of virulence factors in Vibrio vulnificus
Prof. Sang Ho Choi
Vibrio vulnificus produces various virulence factors that enhance its fitness in changing environments as well as host cell-damaging activities and inflammatory responses during infection.
CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation
Prof. Je-Yoel Cho
Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses.
Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasi...
Prof. Hyunsook Lee & Prof. Seong Keun Kim
BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis.
Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by lase...
Prof. Seung Hwan Ko
The patterning of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels with excellent electrical property and spatial resolution is a challenge for bioelectronic applications.
Multi-omics-based autophagy-related untypical subtypes in patients with cerebral amyloid pathology
Prof. Inhee Mook
Recent multi-omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite the possibility of biological subtypes within these patients. For this study, unsupervised classification of four datasets (genetics, miRNA transcriptomics, proteomics, and blood-based biomarkers) using Multi-Omics Factor Analysis+ (MOFA+),
The size of the land carbon sink in China
Prof. Sujong Jeong
A substantial part of China’s anthropogenic emissions has been offset by its land carbon sink, which represents an important element in achieving carbon neutrality by 2060.
Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes
Prof. Jae Bum Kim
Thermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not thoroughly understood.