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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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SlH3 and SlH4 promote multicellular Trichome formation and elongation by upregulating woolly in tomato

SlH3 and SlH4 promote multicellular Trichome formation and elongation by upregulating woolly in tomato

Prof. Jin-Ho Kang

Trichomes are tiny outgrowths on the plant epidermis that serve defensive purposes against various stresses. While the regulatory mechanisms underlying unicellular trichome development are well understood, those governing multicellular trichome formation remain largely unexplored.

Seoul National University

Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism

Prof. Younghoon Kim

Atopic dermatitis (AD) is a globally prevalent chronic inflammatory skin disorder. Its pathogenesis remains incompletely understood, resulting in considerable therapeutic challenges. Recent studies have highlighted the significance of the interaction between AD and gut microbiome.

Seoul National University

Identification of a new bovine picornavirus (Boosepivirus) in the Republic of Korea

Prof. Joon-Seok Chae

This is the first study to determine the prevalence and molecular characteristics of BooV in calf diarrhea in the ROK, highlighting the potential importance of BooV as a causative agent of calf diarrhea and highlighting the need for further research on its epidemiology and pathogenicity.

SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells

SARS-CoV-2 pseudovirus dysregulates hematopoiesis and induces inflammaging of hematopoietic stem and progenitor cells

Prof. Kyung-Rok Yu

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection primarily affects the respiratory system but may induce hematological alterations such as anemia, lymphopenia and thrombocytopenia. Previous studies have reported that SARS-CoV-2 efficiently infects hematopoietic stem and progenitor cells (HSPCs); however, the subsequent effects on hematopoiesis and immune reconstitution have not yet been described.

Contributing factors to the length of stay and discharge destination of home health care patients: 10-year electronic health record analysis using the Donabedian model

Contributing factors to the length of stay and discharge destination of home health care patients: 10-year electronic health record analysis using the Donabedian model

Prof. Kyungmi Woo

Professor Kyungmi Woo’s research team from the College of Nursing at Seoul National University has conducted a comprehensive 10-year analysis of home health care patients using electronic health records. The study identified key factors influencing the length of stay and discharge destination, highlighting the critical role of nursing process variables such as visit frequency, nursing service and patient’s insurance type.

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection

Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection

Prof. Joo Ho Lee

Glioblastoma recurs despite surgery, with poor survival (~1 year). Our study reveals neural stem cells in the subventricular zone (SVZ) as the origin of recurrence. Genomic analysis confirmed SVZ-derived cancer-initiating cells drive relapse. Blocking CXCR4 reduced recurrence and improved survival by 60-70%, offering a new therapeutic strategy.

Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy

Structural diversity of mitochondria in the neuromuscular system across development revealed by 3D electron microscopy

Prof. Junho Lee

As an animal matures, its neural circuit undergoes alterations, yet the developmental changes in intracellular organelles to facilitate these changes is less understood.

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated <i>BRAF</i> mutant mouse models

Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models

Prof. Yong-Seok Lee

RAS/MAPK pathway mutations often induce RASopathies with overlapping features, such as craniofacial dysmorphology, cardiovascular defects, dermatologic abnormalities, and intellectual disabilities. Although BRAF gene mutations are associated with cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome, it remains unclear how these mutations impair cognition.

Professor Gwan-Hyoung Lee's Research Team at Seoul National University Develops a New Synthesis Technology of Single Crystal 2D Semiconductors, “Hypotaxy”, to Enhance the Commercialization of Next-Generation 2D Semiconductors

Professor Gwan-Hyoung Lee's Research Team at Seoul National University Develops a New Synthesis Technology of Single Crystal 2D Semiconductors, “Hypotaxy”, to Enhance the Commercialization of Next-Generation 2D Semiconductors

Professor Gwan-Hyoung Lee

College of Engineering at Seoul National University announced that a research team led by Professor Gwan-Hyoung Lee from the Department of Materials Science and Engineering, in collaboration with the research teams of Professors Hyejin Jang and Jeong Woo Han from the same department, has successfully developed the new synthesis technology of 2D semiconductors.

On-patient medical record and mRNA therapeutics using intradermal microneedles

On-patient medical record and mRNA therapeutics using intradermal microneedles

Prof. Jooli Han

Professor Jooli Han from the Department of Biomedical Engineering at SNU College of Medicine has developed a reliable on-patient medical record and mRNA vaccine delivery system using deep learning and intradermal microneedles.

Professor Jungwon Park's Research Team at Seoul National University Develops World’s First Technology to Observe Atomic Structural Changes of Nanoparticles in 3D

Professor Jungwon Park's Research Team at Seoul National University Develops World’s First Technology to Observe Atomic Structural Changes of Nanoparticles in 3D

Professor Jungwon Park

Seoul National University College of Engineering announced that Professor Jungwon Park’s research team from the Department of Chemical and Biological Engineering has developed a groundbreaking technology to observe atomic structural changes of nanoparticles in three dimensions.

Permafrost Continues to Emit Carbon After delayed Net-Zero... A ‘Red Flag’ for Climate Mitigation

Permafrost Continues to Emit Carbon After delayed Net-Zero... A ‘Red Flag’ for Climate Mitigation

Prof. Jong-Seong Kug

Professor Jong-seong Kug’s research team from School of Earth and Environmental Sciences at SNU revealed that the permafrost ecosystem carbon loss may continue under net-zero and negative emissions, which could hinder climate change mitigation efforts.