Professor Lee's group and colleagues from the Department of Biomedical Sciences at SNU College of Medicine have identified a novel pathological mechanism of Alzheimer’s disease, which opens first-in-class therapeutic strategies.

Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior.

Underrepresentation of non-European (EUR) populations hinders growth of global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects.

Most stars form in multiple-star systems. For a better understanding of their formation processes, it is important to resolve the individual protostellar components and the surrounding envelope and disk material at the earliest possible formation epoch, because the formation history can be lost in a few orbital timescales.

Emerging new-generation geostationary satellites have broadened the scope for studying the diurnal cycle of ecosystem functions. We exploit observations from the Geostationary Operational Environmental Satellite-R series to examine the effect of a severe U.S. heatwave in 2020 on the diurnal variations of ecosystem photosynthesis.

Li-ion battery electrodes exhibit a poorly understood resistance increase during high-rate lithiation, which is rarely observed during delithiation. This hysteresis, often attributed to the solid-state diffusion effect, has not been clearly understood.

Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer's disease (AD) by increasing ER-mitochondria connectivity, in which amyloid β (Aβ) processing occurs rigorously because of its lipid raft-rich characteristics.

Synthetic plastic is used throughout daily life and industry, threatening organisms with microplastic pollution. Polystyrene is a major plastic polymer and also widely found sources of plastic wastes and microplastics.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.

Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death.

Researchers have successfully mapped the dog epigenome and created a high-quality reference map driving new understanding and opening new avenues for functional genomics research in dogs and comparative studies with humans and other species.

CsV3Sb5 exhibits superconductivity at Tc = 3.2 K after undergoing intriguing two high-temperature transitions: charge density wave order at ~98 K and electronic nematic order at Tnem ~ 35 K.