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Proposing New Evolutionary Connections from 214 Million Predicted Protein Structure Database
Prof. Martin Steinegger
Prof. Steinegger‘s team from the Department of Biological Science at SNU has unlocked the gate to the large predicted protein structure AlphaFold Database by clustering the 214M structures into 2M shape-groups, revealing putative homology in prokaryotic species to human immune-related proteins.
Research Highlights Board
Novel pathological mechanism of Alzheimer’s disease uncovered
Prof. Min Jae Lee
Professor Lee's group and colleagues from the Department of Biomedical Sciences at SNU College of Medicine have identified a novel pathological mechanism of Alzheimer’s disease, which opens first-in-class therapeutic strategies.
Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
Prof. Sung Joong Lee
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior.
A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants
Prof. Jong-il Kim
Underrepresentation of non-European (EUR) populations hinders growth of global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects.
Triple spiral arms of a triple protostar system imaged in molecular lines
Prof. Jeong-Eun Lee
Most stars form in multiple-star systems. For a better understanding of their formation processes, it is important to resolve the individual protostellar components and the surrounding envelope and disk material at the earliest possible formation epoch, because the formation history can be lost in a few orbital timescales.
New-generation geostationary satellite reveals widespread midday depression in dryland photosynthesis during 2020 western U.S. heatwave
Prof. Youngryel Ryu
Emerging new-generation geostationary satellites have broadened the scope for studying the diurnal cycle of ecosystem functions. We exploit observations from the Geostationary Operational Environmental Satellite-R series to examine the effect of a severe U.S. heatwave in 2020 on the diurnal variations of ecosystem photosynthesis.
Dynamic surface phases controlling asymmetry of high-rate lithiation and delithiation in phase-separating electrodes
Prof. Jongwoo Lim
Li-ion battery electrodes exhibit a poorly understood resistance increase during high-rate lithiation, which is rarely observed during delithiation. This hysteresis, often attributed to the solid-state diffusion effect, has not been clearly understood.
Glucocorticoid enhances presenilin1-dependent Aβ production at ER's mitochondrial-associated membrane by downregulating Rer1 in neuronal cells
Prof. Ho Jae Han
Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer's disease (AD) by increasing ER-mitochondria connectivity, in which amyloid β (Aβ) processing occurs rigorously because of its lipid raft-rich characteristics.
Polystyrene microplastics biodegradation by gut bacterial Enterobacter hormaechei from mealworms under anaerobic conditions: Anaerobic oxidation and depolymerization
Prof. Younghoon Kim
Synthetic plastic is used throughout daily life and industry, threatening organisms with microplastic pollution. Polystyrene is a major plastic polymer and also widely found sources of plastic wastes and microplastics.
Super-resolution proximity labeling reveals antiviral protein network and its structural changes against SARS-CoV-2 viral proteins
Prof. Hyun-Woo Rhee
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.
Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells
Prof. Junho Lee
Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death.
Scientists unlock the dog epigenome
Prof. Je-Yoel Cho
Researchers have successfully mapped the dog epigenome and created a high-quality reference map driving new understanding and opening new avenues for functional genomics research in dogs and comparative studies with humans and other species.
Optimized superconductivity in the vicinity of a nematic quantum critical point in the kagome superconductor Cs(V1-xTix)3Sb5
Prof. Kee Hoon Kim
CsV3Sb5 exhibits superconductivity at Tc = 3.2 K after undergoing intriguing two high-temperature transitions: charge density wave order at ~98 K and electronic nematic order at Tnem ~ 35 K.