Research Research Highlights
Research Highlights
Research Highlights
Research Highlights
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![The Secret to Satiety Unveiled by Seoul National University Researchers!](/webdata/boardimages/enhighlight/d97z1cfz1a9za1bz93dz8a1z817ze02z714z9c6z75.png)
The Secret to Satiety Unveiled by Seoul National University Researchers!
Prof. Hyung Jin Choi
Professor Hyung Jin Choi's research team from the Department of Brain and Cognitive Sciences at Seoul National University has announced that they have identified the mechanism by which 'glucagon-like peptide-1 (GLP-1)' based obesity treatments reduce body weight for the first time in the world.
Research Highlights Board
![Lysosomal control of senescence and inflammation through cholesterol partitioning](/webdata/boardimages/enhighlight/227z646z3e5z840z483zd71ze5az7daz9dcz1e7z51.jpg)
Lysosomal control of senescence and inflammation through cholesterol partitioning
Prof. Chanhee Kang
Whereas cholesterol is vital for cell growth, proliferation, and remodeling, dysregulation of cholesterol metabolism is associated with multiple age-related pathologies. Here we show that senescent cells accumulate cholesterol in lysosomes to maintain the senescence-associated secretory phenotype (SASP).
![Photocatalytic C–O coupling enzymes that operate via intramolecular electron transfer](/webdata/boardimages/enhighlight/630z61ez4b6zdecza96z78fz4f7z585z77dzadcz98.jpg)
Photocatalytic C–O coupling enzymes that operate via intramolecular electron transfer
Prof. Woon Ju Song
Efficient and environmentally friendly conversion of light energy for direct utilization in chemical production has been a long-standing goal in enzyme design.
![Sequence determinant of small RNA production by DICER](/webdata/boardimages/enhighlight/069z878z36ezd12z891ze56z4f2z16az004z8f7z6e.jpg)
Sequence determinant of small RNA production by DICER
Prof. V. Narry Kim
RNA silencing relies on specific and efficient processing of double-stranded RNA by Dicer, which yields microRNAs (miRNAs) and small interfering RNAs (siRNAs).
![Suppression of cuticular wax biosynthesis mediated by rice LOV KELCH REPEAT PROTEIN 2 supports a negative role in drought stress tolerance](/webdata/boardimages/enhighlight/2adz8cczeb2zc6bz22czcebzb55z2e8z933z37dz52.jpg)
Suppression of cuticular wax biosynthesis mediated by rice LOV KELCH REPEAT PROTEIN 2 supports a negative role in drought stress tolerance
Prof. Nam-Chon Paek
Drought tolerance is important for grain crops, including rice (Oryza sativa); for example, rice cultivated under intermittent irrigation produces less methane gas compared to rice grown in anaerobic paddy field conditions, but these plants require greater drought tolerance.
![Cucurbitacin and volatile compound profiling reveals independent domestication of cucumber (Cucumis sativus L.) fruit](/webdata/boardimages/enhighlight/10az19fz58fzdc2za42z65cz515ze4fza04z250z52.jpg)
Cucurbitacin and volatile compound profiling reveals independent domestication of cucumber (Cucumis sativus L.) fruit
Prof. Eun Jin Lee
Cucurbitacins and volatile compounds of cucumber fruit of 69 genotypes were profiled. Cucurbitacin C was only detected, while other types were not detected. Distinct genotype traits were classified into four groups based on compound profiles. Volatile compounds in F1 hybrids were lower than those in parents and mid-parents.
![Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo](/webdata/boardimages/enhighlight/c89z152z3c2zc4azdb0zf07z4acz80bza40z30dzb3.jpg)
Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo
Prof. Bong-Kiun Kaang
As basic units of neural networks, ensembles of synapses underlie cognitive functions such as learning and memory. These synaptic engrams show elevated synaptic density among engram cells following contextual fear memory formation.
![Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation](/webdata/boardimages/enhighlight/af6ze7cz56az070zcccz39czbfcz70ez321z0adz48.jpg)
Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation
Prof. Kyung-Sun Kang
Decellularized extracellular matrix scaffold, widely utilized for organ engineering, often undergoes matrix decomposition after transplantation and produces byproducts that cause inflammation, leading to clinical failure.
![Mitochondrial Fragmentation and Donut Formation Enhance Mitochondrial Secretion to Promote Osteogenesis](/webdata/boardimages/enhighlight/1b3z663z783za83za3az6cfz302z136z4e9z8fcza6.jpg)
Mitochondrial Fragmentation and Donut Formation Enhance Mitochondrial Secretion to Promote Osteogenesis
Prof. Yun-Sil Lee
Mitochondrial fission and donut formation increase during osteoblast maturation. Fragmented mitochondria and MDVs are secreted extracellularly during osteogenesis. Increasing mitochondrial fission through OPA1 downregulation enhances osteogenesis. Treatment of osteoblast-secreted mitochondria accelerates bone regeneration.
![Development of spleen targeting H2S donor loaded liposome for the effective systemic immunomodulation and treatment of inflammatory bowel disease](/webdata/boardimages/enhighlight/8b1z002zee7za00z4b5z647zba9za2azc92z16bzb4.jpg)
Development of spleen targeting H2S donor loaded liposome for the effective systemic immunomodulation and treatment of inflammatory bowel disease
Prof. Hyung-Jun Im
Nanoparticles are primarily taken up by immune cells after systemic administration. Thus, they are considered an ideal drug delivery vehicle for immunomodulation.
![Engineering DNA-based synthetic condensates with programmable material properties, compositions, and functionalities](/webdata/boardimages/enhighlight/e85z481zbbfz532z897zbefz5e7zc51zd7ez3b5zff.jpg)
Engineering DNA-based synthetic condensates with programmable material properties, compositions, and functionalities
Prof. YONGDAE SHIN & DO-NYUN KIM
Biomolecular condensates participate in diverse cellular processes, ranging from gene regulation to stress survival. Bottom-up engineering of synthetic condensates advances our understanding of the organizing principle of condensates
![Association between antibiotics and dementia risk: A retrospective cohort study](/webdata/boardimages/enhighlight/37ezf07z642z70fza9cz7ffzd73z518z792zef6zf3.jpg)
Association between antibiotics and dementia risk: A retrospective cohort study
Prof. Sang Min Park
The possible relation between antibiotic exposure and the alteration of gut microbiota, which may affect dementia risk, has been revealed. However, the association between antibiotics and dementia incidence has rarely been studied.
![Widespread false gene gains caused by duplication errors in genome assemblies](/webdata/boardimages/enhighlight/a11z6e6z8b2z7e5z334zd29z622zb5fz03fz85bzd7.jpg)
Widespread false gene gains caused by duplication errors in genome assemblies
Prof. Heebal Kim
False duplications in genome assemblies lead to false biological conclusions. We quantified false duplications in popularly used previous genome assemblies for platypus, zebra finch, and Anna’s Hummingbird, and their new counterparts of the same species generated by the Vertebrate Genomes Project, of which the Vertebrate Genomes Project pipeline attempted to eliminate false duplications through haplotype phasing and purging.