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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Targeted degradation of α-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

Targeted degradation of α-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

Prof. Yong Tae Kwon

There are currently no disease-modifying therapeutics for Parkinson’s disease (PD). Although extensive efforts were undertaken to develop therapeutic approaches to delay the symptoms of PD, untreated α-synuclein (α-syn) aggregates cause cellular toxicity and stimulate further disease progression.

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ

TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ

Prof. Ho Jae Han

Lysosomal dysfunction is a pathogenic link that may explain the causal relationship between diabetes and Alzheimer disease; however, there is no information about the regulation of hyperglycemia in neuronal lysophagy modulating lysosomal function.

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities

Prof. Kee Hoon Sohn

Some nucleotide-binding and leucine-rich repeat receptors (NLRs) indirectly detect pathogen effectors by monitoring their host targets.

Harnessing a paper-folding mechanism for reconfigurable DNA origami

Harnessing a paper-folding mechanism for reconfigurable DNA origami

Prof. Do-Nyun Kim

Professor Kim Do-Nyun's research team from the Department of Mechanical Engineering at Seoul National University has succeeded in developing DNA nanotechnology, which allows for the folding or unfolding of a single structure into various shapes, harnessing the paper-folding mechanism.

Functional viromic screens uncover regulatory RNA elements

Functional viromic screens uncover regulatory RNA elements

Prof. V. Narry Kim

The number of sequenced viral genomes has surged recently, presenting an opportunity to understand viral diversity and uncover unknown regulatory mechanisms.

Association of antibiotic use with risk of lung cancer: A nationwide cohort study

Association of antibiotic use with risk of lung cancer: A nationwide cohort study

Prof. Sang Min Park

Although recent studies indicated that antibiotics may be a risk factor for lung cancer, further understanding is needed. We investigated the association of long-term antibiotic exposure with lung cancer risk.

Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction

Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction

Prof. Seung Hyeok Seok, Prof. Hae-Young Lee

The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) and dual SGLT1/2 inhibitor sotagliflozin (SOTA) are emerging as heart failure (HF) medications in addition to having glucose-lowering effects in diabetes mellitus (DM).

Drift of Earth’s Pole Confirms Groundwater Depletion as a Significant Contributor to Global Sea Level Rise 1993-2010

Drift of Earth’s Pole Confirms Groundwater Depletion as a Significant Contributor to Global Sea Level Rise 1993-2010

Prof. Ki-Weon Seo

Climate model estimates show significant groundwater depletion during the 20th century, consistent with global mean sea level (GMSL) budget analysis. However, prior to the Argo float era, in the early 2000’s, there is little information about steric sea level contributions to GMSL, making the role of groundwater depletion in this period less certain.

Machine learning based estimation of urban on-road CO2 concentration in Seoul

Machine learning based estimation of urban on-road CO2 concentration in Seoul

Prof. Sujong Jeong

The urban on-road CO2 emissions will continue to increase, it is therefore essential to manage urban on-road CO2 concentrations for effective urban CO2 mitigation. However, limited observations of on-road CO2 concentrations prevents a full understanding of its variation.

Liquid Metal based Stretchable Room Temperature Soldering Sticker Patch for Stretchable Electronics Integration

Liquid Metal based Stretchable Room Temperature Soldering Sticker Patch for Stretchable Electronics Integration

Prof. Seung Hwan Ko

Researchers are eagerly developing various stretchable conductors to fabricate devices for next-generation electronics. Most of the major problems in stretchable electronics happen at the connection between rigid and soft parts and the development of reliable soldering material is a major hurdle in stretchable electronics.

Fast and accurate protein structure search with Foldseek

Fast and accurate protein structure search with Foldseek

Prof. Martin Steinegger

As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a structural alphabet.

Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C−N Linkage Formed by CYP450 Catalysis

Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C−N Linkage Formed by CYP450 Catalysis

Prof. Dong-Chan Oh, Prof. Seokhee Kim

Chemical analysis of volcanic-island-derived Streptomyces uncovered cihunamides, unique ribosomally synthesized and post-translationally modified peptides with antibacterial activity.