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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Electrically Confined Electroluminescence of Neutral Excitons in WSe2 Light-Emitting Transistors

Electrically Confined Electroluminescence of Neutral Excitons in WSe2 Light-Emitting Transistors

Prof. Gwan-Hyoung Lee

Professor Gwan-Hyoung Lee's research team from the Department of Materials Science and Engineering at SNU has reported the electrically confined electroluminescence of neutral excitons in 2D light-emitting transistors.

Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy

Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy

Prof. Kangwon Lee

Professor Kangwon Lee's research team from the Department of Applied Bioengineering at SNU succeeded in identifying the effects of safe combination anti-cancer treatment with X-ray irradiation using ferroptosis-inducing nanoparticles.

Ubiquitin Ligase RNF20 Coordinates Sequential Adipose Thermogenesis with Brown and Beige Fat-Specific Substrates

Ubiquitin Ligase RNF20 Coordinates Sequential Adipose Thermogenesis with Brown and Beige Fat-Specific Substrates

Prof. Jae Bum Kim

In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli.

Molecular characterization of <i>Fusarium venenatum</i>-based microbial protein in animal models of obesity using multi-omics analysis

Molecular characterization of Fusarium venenatum-based microbial protein in animal models of obesity using multi-omics analysis

Prof. Younghoon Kim

Microbial protein, produced by fermentation of Fusarium venenatum is a promising candidate alternative protein source. Previous study has demonstrated its ability to improve hyperlipidemia in rats, yet the related mechanism remains unclear.

Missing methane emissions from urban sewer networks

Missing methane emissions from urban sewer networks

Prof. Sujong Jeong

Methane emissions from sewer networks are an important source of anthropogenic greenhouse gases (GHGs) but are not currently reflected in the national GHG inventory.

Targeting class A GPCRs for hard tissue regeneration

Targeting class A GPCRs for hard tissue regeneration

Prof. Jin Man Kim

This study present a strategy for targeting GPCRs for hard tissue regeneration by promoting the biomineralization of mesenchymal stromal cells. The discovered GPCR-targeting drugs revealed potent regenerative effects in both tooth and bone defects.

IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

Prof. Jin-Hong Kim

Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair.

Deciphering natural and anthropogenic sources of nitrous oxide

Deciphering natural and anthropogenic sources of nitrous oxide

Prof. Jinho Ahn

Nitrous oxide (or nitrous oxide, N2O) is a major greenhouse gas, along with carbon dioxide (CO2) and methane (CH4), and is about 300 times more potent than CO2.

Low temperature-mediated repression and far-red light-mediated induction determine morning <i>FLOWERING LOCUS T</i> expression levels

Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

Prof. Young Hun Song

In order to flower in the appropriate season, plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis (Arabidopsis thaliana) FLOWERING LOCUS T (FT).

Decoupling NAD<sup>+</sup> metabolic dependency in chondrosarcoma by targeting the SIRT1–HIF-2α axis

Decoupling NAD⁺ metabolic dependency in chondrosarcoma by targeting the SIRT1–HIF-2α axis

Prof. Jin-Hong Kim

Chondrosarcomas represent the second most common primary bone malignancy. Despite the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD) depletion, targeting the NAD+ synthesis pathway remains challenging due to broad implications in biological processes.

Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Prof. Yoo-Sun Noh

The phytohormone salicylic acid (SA) triggers transcriptional reprogramming that leads to SA-induced immunity in plants. NPR1 is an SA receptor and master transcriptional regulator in SA-triggered transcriptional reprogramming.

Seoul National University

Identification of specific neutralizing antibodies for highly pathogenic avian influenza H5 2.3.4.4b clades to facilitate vaccine design and therapeutics

Prof. Seon Ju Yeo

The highly pathogenic avian influenza H5 2.3.4.4 and 2.3.2.1c subclades have distinct antigenic properties and are responsible for the majority of human infections.