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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Novel pathological mechanism of Alzheimer’s disease uncovered

Novel pathological mechanism of Alzheimer’s disease uncovered

Prof. Min Jae Lee

Professor Lee's group and colleagues from the Department of Biomedical Sciences at SNU College of Medicine have identified a novel pathological mechanism of Alzheimer’s disease, which opens first-in-class therapeutic strategies.

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

Prof. Sung Joong Lee

Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others. Astrocytes are implicated in optimizing the balance between excitatory and inhibitory (E/I) neuronal activity, which may influence social behavior.

A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

Prof. Jong-il Kim

Underrepresentation of non-European (EUR) populations hinders growth of global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects.

Triple spiral arms of a triple protostar system imaged in molecular lines

Triple spiral arms of a triple protostar system imaged in molecular lines

Prof. Jeong-Eun Lee

Most stars form in multiple-star systems. For a better understanding of their formation processes, it is important to resolve the individual protostellar components and the surrounding envelope and disk material at the earliest possible formation epoch, because the formation history can be lost in a few orbital timescales.

New-generation geostationary satellite reveals widespread midday depression in dryland photosynthesis during 2020 western U.S. heatwave

New-generation geostationary satellite reveals widespread midday depression in dryland photosynthesis during 2020 western U.S. heatwave

Prof. Youngryel Ryu

Emerging new-generation geostationary satellites have broadened the scope for studying the diurnal cycle of ecosystem functions. We exploit observations from the Geostationary Operational Environmental Satellite-R series to examine the effect of a severe U.S. heatwave in 2020 on the diurnal variations of ecosystem photosynthesis.

Dynamic surface phases controlling asymmetry of high-rate lithiation and delithiation in phase-separating electrodes

Dynamic surface phases controlling asymmetry of high-rate lithiation and delithiation in phase-separating electrodes

Prof. Jongwoo Lim

Li-ion battery electrodes exhibit a poorly understood resistance increase during high-rate lithiation, which is rarely observed during delithiation. This hysteresis, often attributed to the solid-state diffusion effect, has not been clearly understood.

Glucocorticoid enhances presenilin1-dependent Aβ production at ER's mitochondrial-associated membrane by downregulating Rer1 in neuronal cells

Glucocorticoid enhances presenilin1-dependent Aβ production at ER's mitochondrial-associated membrane by downregulating Rer1 in neuronal cells

Prof. Ho Jae Han

Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer's disease (AD) by increasing ER-mitochondria connectivity, in which amyloid β (Aβ) processing occurs rigorously because of its lipid raft-rich characteristics.

Polystyrene microplastics biodegradation by gut bacterial Enterobacter hormaechei from mealworms under anaerobic conditions: Anaerobic oxidation and depolymerization

Polystyrene microplastics biodegradation by gut bacterial Enterobacter hormaechei from mealworms under anaerobic conditions: Anaerobic oxidation and depolymerization

Prof. Younghoon Kim

Synthetic plastic is used throughout daily life and industry, threatening organisms with microplastic pollution. Polystyrene is a major plastic polymer and also widely found sources of plastic wastes and microplastics.

Super-resolution proximity labeling reveals antiviral protein network and its structural changes against SARS-CoV-2 viral proteins

Super-resolution proximity labeling reveals antiviral protein network and its structural changes against SARS-CoV-2 viral proteins

Prof. Hyun-Woo Rhee

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection.

Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells

Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells

Prof. Junho Lee

Telomere length must be maintained in actively dividing cells to avoid cellular arrest or death.

Scientists unlock the dog epigenome

Scientists unlock the dog epigenome

Prof. Je-Yoel Cho

Researchers have successfully mapped the dog epigenome and created a high-quality reference map driving new understanding and opening new avenues for functional genomics research in dogs and comparative studies with humans and other species.

Optimized superconductivity in the vicinity of a nematic quantum critical point in the kagome superconductor Cs(V1-xTix)3Sb5

Optimized superconductivity in the vicinity of a nematic quantum critical point in the kagome superconductor Cs(V1-xTix)3Sb5

Prof. Kee Hoon Kim

CsV3Sb5 exhibits superconductivity at Tc = 3.2 K after undergoing intriguing two high-temperature transitions: charge density wave order at ~98 K and electronic nematic order at Tnem ~ 35 K.