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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration

Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration

Prof. Sung Hee Baek

Professor Sunghee Baek's team at SNU identified PHF16 as key to intestinal homeostasis after injury. PHF16 restores the epithelium by activating RAR/RXR target genes via HBO1 histone acetylation and suppressing YAP/TAZ via CDC73 ubiquitination. Its role offers insights for gut repair therapies.

A Natural Laboratory for Astrochemistry: The Variable Protostar B335

A Natural Laboratory for Astrochemistry: The Variable Protostar B335

Prof. Jeong-Eun Lee

Emission lines from complex organic molecules in B335 were observed in four epochs, spanning a luminosity burst of about 10 years duration. The emission lines increased dramatically in intensity as the luminosity increased, but they have decreased only slightly as the luminosity has decreased.

Neuroplasticity-enhancing therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of sequelae of cerebral infarction

Neuroplasticity-enhancing therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of sequelae of cerebral infarction

Prof. Mi-Sook Chang

Despite a dramatic increase in ischemic stroke incidence worldwide, effective therapies for attenuating sequelae of cerebral infarction are lacking. This study investigates the use of human mesenchymal stem cells (hMSCs) induced toward glia-like cells (ghMSCs) to ameliorate chronic sequelae resulting from cerebral infarction.

Structural insight into the distinct regulatory mechanism of the HEPN-MNT toxin-antitoxin system in <i>Legionella pneumophila</i>

Structural insight into the distinct regulatory mechanism of the HEPN-MNT toxin-antitoxin system in Legionella pneumophila

Prof. Byung Woo Han

HEPN-MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity.

Calcium ion-triggered liquid-liquid phase separation of silk fibroin and spinning through acidification and shear stress

Calcium ion-triggered liquid-liquid phase separation of silk fibroin and spinning through acidification and shear stress

Prof. Ki Hoon Lee

Professor Ki Hoon Lee's research team from the Department of Agriculture, Forestry, and Bioresources at SNU developed a biomimetic spinning process by leveraging silk fibroin's liquid-liquid phase separation, followed by acidification and shear force to produce fibers.

Conserved effector families render <i>Phytophthora</i> species vulnerable to recognition by NLR receptors in nonhost plants

Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants

Prof. Doil Choi

Prof. Doil Choi and research team identified multiple resistance genes against various Phytophthora pathogens that threat wide-range of important crop species

Professor Seung Hwan Ko's Research Team at Seoul National University Develops Filter-Free Microbubble Air Purification System

Professor Seung Hwan Ko's Research Team at Seoul National University Develops Filter-Free Microbubble Air Purification System

Professor Seung Hwan Ko

Seoul National University College of Engineering announced that a research team led by Professor Seung Hwan Ko from the Department of Mechanical Engineering has developed an eco-friendly air purification system using microbubble filters instead of conventional solid filters.

Associations of Changes in Alcohol Consumption on the Risk of Depression/Suicide Among Initial Nondrinkers

Associations of Changes in Alcohol Consumption on the Risk of Depression/Suicide Among Initial Nondrinkers

Prof. Sang Min Park

Although prior studies showed the association between the amount of alcohol ingestion and the risk of depression and suicide, there has been a lack of research considering changes in alcohol intake over time.

Measurements of the quantum geometric tensor in solids

Measurements of the quantum geometric tensor in solids

Prof. Bohm-Jung Yang

Understanding the geometric properties of quantum states and their implications in fundamental physical phenomena is a core aspect of contemporary physics.

Water and gas geochemistry of springs in Ulleungdo volcano, South Korea: Implications for degassing of upper mantle-derived volatiles in Northeast Asia

Water and gas geochemistry of springs in Ulleungdo volcano, South Korea: Implications for degassing of upper mantle-derived volatiles in Northeast Asia

Prof. Hyunwoo Lee

Ulleungdo, a volcanic island located in the back-arc basin (East Sea/Sea of Japan) of the Japanese arc, is one of the Cenozoic intraplate volcanoes in Northeast (NE) Asia.

SNU Department of Electrical and Computer Engineering's Optical Engineering and Quantum Electronics Laboratory, Develops Ultra-Compact Camera Technology Optimized for VR/AR Devices

SNU Department of Electrical and Computer Engineering's Optical Engineering and Quantum Electronics Laboratory, Develops Ultra-Compact Camera Technology Optimized for VR/AR Devices

Seoul National University College of Engineering announced that researchers from the Department of Electrical and Computer Engineering’s Optical Engineering and Quantum Electronics Laboratory have developed an optical design technology that dramatically reduces the volume of cameras with a folded lens system utilizing “metasurfaces,” a next-generation nano-optical device.

Nuclear localization sequence of MoHTR1, a <i>Magnaporthe oryzae</i> effector, for transcriptional reprogramming of immunity genes in rice

Nuclear localization sequence of MoHTR1, a Magnaporthe oryzae effector, for transcriptional reprogramming of immunity genes in rice

Prof. Yong-Hwan Lee

Plant pathogens secrete nuclear effectors into the host nuclei to modulate the host immune system. Although several nuclear effectors of fungal pathogens have been recently reported, the molecular mechanism of NLS-associated transport vehicles of nuclear effectors and the roles of NLS in transcriptional reprogramming of host immunity genes remain enigmatic.