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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Purification of multiplex oligonucleotide libraries by synthesis and selection

Purification of multiplex oligonucleotide libraries by synthesis and selection

Prof. Sunghoon Kwon

Professor Kwon, Sunghoon's research team from the Deparment of Electrical and Computer Engineering of Seoul National University announced that they have developed a super-parallel high-purity nucleic acid(DNA/RNA) purification technology.

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Prof. Bong-Kiun Kaang

Professor Kaang, Bong-Kiun's research team in the School of Biological Sciences revealed the process in which gene mutations lead to autism phenotypes using pluripotent stem cells.

Crustal magmatic controls on the formation of porphyry copper deposits

Crustal magmatic controls on the formation of porphyry copper deposits

Prof. Jung-Woo Park

Professor Park, Jung-Woo's research team in the School of Earth and Environmental Sciences presented a new integrated model for the crust-magma process that affects the formation of porphyry copper deposits.

Redox-neutral electrochemical conversion of CO2 to dimethyl carbonate

Redox-neutral electrochemical conversion of CO2 to dimethyl carbonate

Prof. Ki Tae Nam

Professor Nam, Ki Tae's team of the Department of Materials Science and Engineering announced that they have succeeded in synthesizing carbon dioxide into carbonate for fuel, a new concept of carbon-neutral fuel.

Spectroscopic Detection of Alfvénic Waves in the Chromosphere of Sunspot Regions

Spectroscopic Detection of Alfvénic Waves in the Chromosphere of Sunspot Regions

Prof. Jongchul Chae

Transverse magnetohydrodynamic waves often called Alfvénic (or kink) waves have been often theoretically put forward to solve the outstanding problems of the solar corona like coronal heating, solar wind acceleration, and chemical abundance enhancement.

Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal model

Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal model

Prof. Inhee Mook

Here, we suggest a novel role for the plexin-A4 as an Aβ receptor that induces aggregated tau pathology.

Effect of amino acid-derived nitrogen and/or sulfur doping on the visible-light-driven antimicrobial activity of carbon quantum dots: A comparative study

Effect of amino acid-derived nitrogen and/or sulfur doping on the visible-light-driven antimicrobial activity of carbon quantum dots: A comparative study

Prof. Dong-Hyun Kang

The purpose of this study was to investigate the effects of nitrogen and sulfur derived from amino acids on the visible-light-driven (VLD) antimicrobial activity of carbon quantum dots (CQDs) and to establish an optimal doping form.

Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain

Epigallocatechin Gallate Inhibits the Uridylate-Specific Endoribonuclease Nsp15 and Efficiently Neutralizes the SARS-CoV-2 Strain

Prof. Nam-Chul Ha

This study screened natural compounds in vitro to identify inhibitors against Nsp15 from SARS-CoV-2. Three natural compounds, epigallocatechin gallate (EGCG), baicalin, and quercetin, were identified as potential inhibitors.

Antarctic surface temperature and elevation during the Last Glacial Maximum

Antarctic surface temperature and elevation during the Last Glacial Maximum

Prof. Jinho Ahn

Here, we reconstruct the magnitude and spatial pattern of Last Glacial Maximum surface cooling in Antarctica using borehole thermometry and firn properties in seven ice cores.

Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis

Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis

Prof. Yeo Joon Yoon

Systematic inactivation of nonribosomal peptide synthetase (NRPS) domains and translocation of the thioesterase (TE) domain revealed several unprecedented nonlinear NRPS assembly processes during the biosynthesis of the cyclodepsipeptide WS9326A in Streptomyces sp. SNM55.

Coordinate regulation of the senescent state by selective autophagy

Coordinate regulation of the senescent state by selective autophagy

Prof. Chanhee Kang

Cellular senescence is a complex stress response implicated in aging. Autophagy can suppress senescence but is counterintuitively necessary for full senescence.

The SARS-CoV-2 RNA interactome

The SARS-CoV-2 RNA interactome

Prof. V. Narry Kim

SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs.