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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

Prof. Jin-Hong Kim

Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality.

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

Prof. Heebal Kim

Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown.

Multioperation‐Mode Light‐Emitting Field‐Effect Transistors Based on van der Waals Heterostructure

Multioperation‐Mode Light‐Emitting Field‐Effect Transistors Based on van der Waals Heterostructure

Prof. Gwan‐Hyoung Lee

2D semiconductors have shown great potential for application to electrically tunable optoelectronics.

DNA Micro‐Disks for the Management of DNA‐Based Data Storage with Index and Write‐Once–Read‐Many (WORM) Memory Features

DNA Micro‐Disks for the Management of DNA‐Based Data Storage with Index and Write‐Once–Read‐Many (WORM) Memory Features

Prof. Sunghoon Kwon

DNA‐based data storage has attracted attention because of its higher physical density of the data and longer retention time than those of conventional digital data storage. However, previous DNA‐based data storage lacked index features and the data quality of storage after a single access was not preserved, obstructing...

Novel laser-thermal mechanism realizes ultra-fast construction of PDMS devices

Novel laser-thermal mechanism realizes ultra-fast construction of PDMS devices

Prof. Seung Hwan Ko

Researchers at Seoul National University in South Korea reported the development of new laser-based polydimethylsiloxane (PDMS) processing mechanism that enables the mask-less direct fabrication of various PDMS structures.

Rhizolutin, a novel 7/10/6‐tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer’s disease

Rhizolutin, a novel 7/10/6‐tricyclic dilactone, dissociates misfolded protein aggregates and reduces apoptosis/inflammation associated with Alzheimer’s disease

Prof. Dong-Chan Oh

Rhizolutin ( 1 ) was discovered as a natural product of ginseng‐rhizospheric Streptomyces sp. WON17. Its structure featured an unprecedented 7/10/6‐tricyclic dilactone carbon skeleton composed of dimethylcyclodecatriene flanked by a 7‐membered and a 6‐membered lactone ring based on spectroscopic analysis. During an unb...

A Large‐Scale Array of Ordered Graphene‐Sandwiched Chambers for Quantitative Liquid‐Phase Transmission Electron Microscopy

A Large‐Scale Array of Ordered Graphene‐Sandwiched Chambers for Quantitative Liquid‐Phase Transmission Electron Microscopy

Prof. Jungwon Park

Liquid‐phase transmission electron microscopy (TEM) offers a real‐time microscopic observation of the nanometer scale for understanding the underlying mechanisms of the growth, etching, and interactions of colloidal nanoparticles. Despite such unique capability and potential application in diverse fields of analytical ...

Monolithic digital patterning of polydimethylsiloxane with successive laser pyrolysis

Monolithic digital patterning of polydimethylsiloxane with successive laser pyrolysis

Prof. Seung Hwan Ko & Prof. Noo Li Jeon

The patterning of polydimethylsiloxane (PDMS) into complex two-dimensional (2D) or 3D shapes is a crucial step for diverse applications based on soft lithography. Nevertheless, mould replication that incorporates time-consuming and costly photolithography processes still remains the dominant technology in the field. He...

Quantum distance and anomalous Landau levels of flat bands

Quantum distance and anomalous Landau levels of flat bands

Prof. Bohm-Jung Yang

Semiclassical quantization of electronic states under a magnetic field, as proposed by Onsager, describes not only the Landau level spectrum but also the geometric responses of metals under a magnetic field. Even in graphene with relativistic energy dispersion, Onsager’s rule correctly describes the π Berry phase, as w...

Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

Prof. Ho Jae Han

Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis and induces neuropathological changes, such as impaired neuronal integrity, neurodegeneration, and cognitive impairment.

Resource-Efficient Topological Fault-Tolerant Quantum Computation with Hybrid Entanglement of Light

Resource-Efficient Topological Fault-Tolerant Quantum Computation with Hybrid Entanglement of Light

Prof. Hyunseok Jeong

We propose an all-linear-optical scheme to ballistically generate a cluster state for measurement-based topological fault-tolerant quantum computation using hybrid photonic qubits entangled in a continuous-discrete domain.

Topological Hyperbolic Lattices

Topological Hyperbolic Lattices

Prof. Namkyoo Park

Non-Euclidean geometry, discovered by negating Euclid’s parallel postulate, has been of considerable interest in mathematics and related fields for the description of geographical coordinates, Internet infrastructures, and the general theory of relativity.