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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level

Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level

Prof. Junho Lee

Karyotype change and subsequent evolution is triggered by chromosome fusion and rearrangement events, which often occur when telomeres become dysfunctional.

DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics

DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics

Prof. Jae Bum Kim

White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT dysfunction, obesity, and metabolic complications.

Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis

Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis

Prof. Young-Yun Kong

Age-associated muscle atrophy is a debilitating condition associated with loss of muscle mass and function with age that contributes to limitation of mobility and locomotion.

Realization of superabsorption by time reversal of superradiance

Realization of superabsorption by time reversal of superradiance

Prof. Kyungwon An

Emission and absorption of light lie at the heart of light–matter interaction.

Redirecting dynamic surface restructuring of a layered transition metal oxide catalyst for superior water oxidation

Redirecting dynamic surface restructuring of a layered transition metal oxide catalyst for superior water oxidation

Prof. Jongwoo Lim

Rationally manipulating the in situ formed catalytically active surface of catalysts remains a tremendous challenge for a highly efficient water electrolysis.

Shimiella gen. nov. and Shimiella gracilenta sp. nov. (Dinophyceae, Kareniaceae), a Kleptoplastidic Dinoflagellate from Korean Waters and its Survival under Starvation

Shimiella gen. nov. and Shimiella gracilenta sp. nov. (Dinophyceae, Kareniaceae), a Kleptoplastidic Dinoflagellate from Korean Waters and its Survival under Starvation

Prof. Hae Jin Jeong

A small dinoflagellate, ~13 μm in cell length, was isolated from Jinhae Bay, Korea. Light microscopy showed that it was similar to the kleptoplastidic dinoflagellate Gymnodinium gracilentum nom. inval. rDNA sequences were obtained and its anatomy and morphology described using light and scanning and transmission electr...

Graphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo

Graphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo

Prof. Kyung-Sun Kang

While the neuropathological characteristics of Niemann-Pick disease type C (NPC) result in a fatal diagnosis, the development of clinically available therapeutic agent remains a challenge. Here we propose graphene quantum dots (GQDs) as a potential candidate for the impaired functions in NPC in vivo. In addition to the...

Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells

Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells

Prof. Junho Lee

Telomeres are part of a highly refined system for maintaining the stability of linear chromosomes.

L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

Prof. Kwangseog Ahn

L1 retrotransposons can pose a threat to genome integrity. The host has evolved to restrict L1 replication.

Simple physical mixing of zeolite prevents sulfur deactivation of vanadia catalysts for NOx removal

Simple physical mixing of zeolite prevents sulfur deactivation of vanadia catalysts for NOx removal

Prof. Do Heui Kim

Here, we report that physically mixed H-Y zeolite effectively protects vanadium active sites by trapping ABS in micropores.

An assessment of emission characteristics of Northern Hemisphere cities using spaceborne observations of CO2, CO, and NO2

An assessment of emission characteristics of Northern Hemisphere cities using spaceborne observations of CO2, CO, and NO2

Prof. Sujong Jeong

Intensified anthropogenic activities and high levels of energy consumption in cities have led to an increase in emissions of CO2 and air pollutants, impacting air quality and calling for better measures to monitor and reduce emissions. This study assesses the emission characteristics of cities in the Northern Hemispher...

Synthetic protein quality control to enhance full-length translation in bacteria

Synthetic protein quality control to enhance full-length translation in bacteria

Prof. Sang Woo Seo

Coupled transcription and translation processes in bacteria cause indiscriminate translation of intact and truncated messenger RNAs, inevitably generating nonfunctional polypeptides.