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Media CoverageThe media coverages are summaries of the newspaper articles of the day published about SNU

  • April 22, 2015

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Professor BAEK Sung Hee
Professor BAEK Sung Hee

Professor Sung Hee BAEK’s Research on Pontin and Embryonic Stem Cells

Professor Sung Hee Baek’s research team (Department of Biological Sciences) has found that Pontin chromatin remodeling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse embryonic stem cells. Oct4 is a protein which is critically involved in the self-renewal of undifferentiated embryonic stem cells. Until now, the controlling mechanism of pluripotency of embryonic stem cells remained largely elusive. The research team generated Pontin-deficient mice by gene targeting in embryonic stem cells. Although Pontin heterozygous mice were fertile and showed no detectable developmental abnormalities, none of the Pontin-deficient homozygous animals were obtained from 168 offspring, indicating that lack of Pontin resulted in embryonic lethality. This research, which was funded by the National Research Foundation of Korea and the National Cancer Center, was published in Nature Communications on April 10.

Summary by LEE Hee Un, SNU English Editor, gurume0221@snu.ac.kr
Proofread by Melora Brett Briana Johnson, morningcalm2@gmail.com

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